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Update abiq.md

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......@@ -10,9 +10,33 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF13958
contributors:
- Florian Tesson
relevantAbstracts:
- doi: 10.1023/A:1002027321171
- doi: 10.1016/j.mib.2005.06.006
- doi: 10.1128/AEM.64.12.4748-4756.1998
- doi: 10.1111/mmi.12129
---
# AbiQ
## Description
AbiQ was discovered in 1998 on *Lactococcus lactis* plasmid :ref{doi=10.1128/AEM.64.12.4748-4756.1998}.
AbiQ is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry :ref{doi=10.1016/j.mib.2005.06.006}. AbiQ is classified as abortive infection in :ref{doi=10.1016/j.mib.2023.102312}.
AbiQ is composed of a single protein AbiQ and a RNA anti toxin (antiQ) :ref{doi=10.1111/mmi.12129}.
## Molecular mechanism
AbiQ act as an anti-toxin type III. AbiQ is a RNAase that will bind its antitoxin antiQ :ref{doi=10.1111/mmi.12129}.
The AbiQ is constitutively expressed and bind to its antiQ RNA resulting in a inactivated AbiQ.
To get activated, AbiQ need the concentration of antiQ to decrease.
However, during phage infection, the expression of the antiQ is constant and the author do not know how the AbiQ is activated :ref{doi=10.1111/mmi.12129}.
## Example of genomic structure
The AbiQ is composed of 1 protein: AbiQ.
......@@ -35,6 +59,17 @@ Proportion of genome encoding the AbiQ system for the 14 phyla with more than 50
## Structure
### Experimentaly determined structure
From :ref{doi=10.1111/mmi.12129} in *Lactococcus lactis*:
::molstar-pdbe-plugin
---
height: 700
dataUrl: /abiq/4glk_LlAbiQ_1mer.cif
---
::
### AbiQ
......
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