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Update septu.md

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......@@ -10,9 +10,27 @@ tableColumns:
Activator: Unknown
Effector: Unknown
PFAM: PF13175, PF13304, PF13476
contributors:
- Florian Tesson
relevantAbstracts:
- doi: 10.1016/j.cell.2020.09.065
- doi: 10.1093/nar/gkab883
- doi: 10.1126/science.aar4120
---
# Septu
## Description
The Septu defense system was discovered in 2018 in *Bacillus* :ref{doi=10.1126/science.aar4120}. The name of the system is related to Septu (or Sopdu) the ancient egypt god of the sky and of eastern border regions.
The Septu defense systems is composed of two protein PtuA and PtuB: PtuA encoding for an ATPase (AAA15/AAA21) and PtuB with HNH endonuclease domain.
After the discovery of Septu, two studies discovered separatly another form of Septu :ref{doi=10.1093/nar/gkab883,10.1016/j.cell.2020.09.065}. This new subtype encode a thrid protein with a reverse transcriptase domain. This system is either reffer as Septu Type II :ref{doi=10.1093/nar/gkab883} or as [Retron](/defense-systems/retron) subtype RT-I-A :ref{doi=10.1016/j.cell.2020.09.065,10.1016/j.cell.2020.09.065}.
The Septu defense system is part of large category of system that encode the AAA15/21 ABC ATPase :ref{doi=10.1111/mmi.15074}.
## Molecular mechanism
As far as we are aware, the molecular mechanism is unknown.
## Example of genomic structure
The Septu is composed of 2 proteins: PtuA and PtuB.
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style Title3 fill:none,stroke:none,stroke-width:none
style Title4 fill:none,stroke:none,stroke-width:none
</mermaid>
## Relevant abstracts
::relevant-abstracts
---
items:
- doi: 10.1016/j.cell.2020.09.065
- doi: 10.1093/nar/gkab883
- doi: 10.1126/science.aar4120
---
::
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