Update zorya.md

content/3.defense-systems/zorya.md

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 # Zorya
+
+## Description
+
+The Zorya defense system was discovered in 2018 :ref{doi=10.1126/science.aar4120} among other systems.
+
+The Zorya defense system is composed of two protein ZorA and ZorB in all the subtypes with different other proteins (ZorC + ZorD type I, ZorE type II or ZorF + ZorG type III).
+
+## Molecular mechanism
+
+For Zorya type I:
+
+ZorA and ZorB forms an transmembrane heteromer 5:2 (A:B) acting as a peptidoglycin-binding rotary motor :ref{doi=10.1101/2023.12.18.572097}. The structure show that the 5 ZorA proteins form a long tail inside the cytoplasm. Part of this tail has amino acid homology with the core signaling unit of the bacterial chemosensory array :ref{doi=10.1016/j.sbi.2023.102565} suggesting that the ZorA tail is responsible of the activation of ZorC and ZorD.
+
+On the other hand, ZorC and ZorD interact with DNA :ref{doi=10.1101/2023.12.18.572097} and ZorD act as a ATP dependant nuclease.
+
+With all those results :ref{doi=10.1101/2023.12.18.572097}, the suggested mechanism is:
+
+- Detection of the phage infection by the ZorAB complex (depressed cell wall or inner membrane curvature)
+- Signal transduction from ZorA tail to ZorC and ZorD
+- DNA binding by ZorC/D and DNA cleavage by ZorD close to the injection site.
+
+
 ## Example of genomic structure
 
 A total of 2 subsystems have been described for the Zorya system.
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 items:
     - doi: 10.1093/nar/gkab883
     - doi: 10.1126/science.aar4120
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+    - doi: 10.1101/2023.12.18.572097
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