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Update fs_sma.md

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contributors:
- Héloïse Georjon
relevantAbstracts:
- doi: 10.1016/j.cell.2022.07.014
- doi: 10.1016/j.cell.2022.07.014
---
# SMA
## Description
SMA (single-protein MazF-like antiphage system) was identified in a phage-inducible chromosomal island (PICI) found in *Staphylococcus aureus* ref{doi=10.1016/j.cell.2022.07.014}. SMA was shown to inhibit phage infection and to inhibit the formation of new virions after prophage induction.
SMA (single-protein MazF-like antiphage system) was identified in a phage-inducible chromosomal island (PICI) found in *Staphylococcus aureus* :ref{doi=10.1016/j.cell.2022.07.014}. SMA was shown to inhibit phage infection and to inhibit the formation of new virions after prophage induction.
## Molecular mechanisms
The SMA protein comprises a domain analogous to MazF. MazF a protein that is normally part of the MazEF toxin-antitoxin systems, in which MazF is a toxic endoribonuclease that targets mRNA ref{10.1016/s1097-2765(03)00402-7}.
The SMA protein comprises a domain analogous to MazF. MazF a protein that is normally part of the MazEF toxin-antitoxin systems, in which MazF is a toxic endoribonuclease that targets mRNA :ref{doi=10.1016/s1097-2765(03)00402-7}.
As far as we are aware, the precise molecular mechanism of SMA is unknown.
## Example of genomic structure
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