_ROCK_ (Reducing Over-Covering K-mers) is a command line program written in [C++](https://isocpp.org/) that runs an alternative implementation of the _digital normalization_ method (e.g. Brown et al. 2012, Wedemeyer et al. 2017, Durai and Schulz 2019).
_ROCK_ (Reducing Over-Covering K-mers) is a command line program written in [C++](https://isocpp.org/) that runs an alternative implementation of the _digital normalization_ method (e.g. Brown et al. 2012, Wedemeyer et al. 2017, Durai and Schulz 2019).
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_ROCK_ can therefore be used to reduce and/or homogenize the overall coverage depth within large sets of HTS reads, which is often required to quickly infer accurate _de novo_ genome assemblies (e.g. Desai et al. 2013, Chen et al. 2015).
_ROCK_ can therefore be used to reduce and/or homogenize the overall coverage depth within large sets of HTS reads, which is often required to quickly infer accurate _de novo_ genome assemblies (e.g. Desai et al. 2013, Chen et al. 2015).
_ROCK_ can also be used to discard low-covering HTS reads, as those ones are often artefactual, highly erroneous or contaminating sequences.
_ROCK_ can also be used to discard low-covering HTS reads, as those ones are often artefactual, highly erroneous or contaminating sequences.
For more details, see the associated publication: Legrand et al. (2022)[](https://doi.org/10.21105/joss.03790)
For more details, see the associated publication: Legrand et al. (2022).
