Rst rt nitrilase tm

content/3.defense-systems/rst_rt-nitrilase-tm.md

@@ -10,11 +10,25 @@ tableColumns:
     Activator: Unknown
     Effector: Unknown
     PFAM: PF00078
+contributors:
+    - Hugo Vaysset
 relevantAbstracts:
     - doi: 10.1016/j.chom.2022.02.018
+    - doi: 10.1093/nar/gkac467
 ---
 
-# Rst_RT-nitrilase-Tm
+# RT-nitrilase-Tm
+
+## Description
+RT-nitrilase-Tm (also named UG5-large) is a two genes defense system. It was discovered from P4-like satellites in *E. coli* genomes :ref{doi=10.1016/j.chom.2022.02.01} :ref{doi=10.1093/nar/gkac467}. Its antiphage activity was shown in *E. coli* against phage AL505_P2 (Myoviridae). 
+
+The first protein is a reverse transcriptase (RT) fussed with C-N hydrolase domain (nitrilase) ; the second protein is transmembrane protein :ref{doi=10.1093/nar/gkac467}.
+
+The presence of a RT protein allows to draw a parallel between this system and the [DRT defense system](/defense-systems/drt).
+
+## Molecular mechanism
+As far as we are aware, the molecular mechanism is unknown. 
+
 ## Example of genomic structure
 
 The Rst_RT-nitrilase-Tm is composed of 2 proteins: RT and RT-Tm.